2011•Journal of clinical and experimental medicineRequires access

Effects of maFGF on the activities of Na~+-K~+-ATPase and Ca~(2+)-Mg~(2+)-ATPase in liver tissue of D-galactose-induced aging model rats.

Lan Xian-jun

Abstract

Objective To study the effects of modified acidic fibroblast growth factor(maFGF) on the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in liver tissue of D-galactose-induced aging model rats.Methods The rat aging model was established by injection of D-galactose.Wistar rats were randomly divided into control group,model of aging group,normal saline(NS) and maFGF treatment group.The activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in liver tissue were detected.Results The activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in liver tissue in model of aging group were significantly decreased than those in control group(P0.01).After maFGF intervention,the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in liver tissue of the maFGF group were significantly increased compared with the NS group and model of aging group respectively(P0.05).Conclusion maFGF can increase the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase in liver tissue in D-galactose-induced aging model rats.

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Key concepts: ATPase, Liver tissue, Internal medicine, Endocrinology, Galactose, Medicine, Rat model, Enzyme