Comparison of curative effect of mycophenolate mofetil and cyclophos-phamide for the treatment of refractory lupus nephritis

Objective To compare the clinical efficacy and safety of mycophenolate mofetil(MMF)and cyclophos phamide(CTX) combined prednisone therapy refractory lupus nephritis(LN). Methods Seventy-nine patients with refractory lupus nephritis were randomly divided into two groups. Thirty-nine cases were treated with prednisone plus mycophenolate mofetil in treatment group. Forty cases were treated with prednisone plus cyclophosphamide in control group.Ttreatment course was two years, compared two groups before and after treatment, 24 h urinary protein, serum ANA, the change of plasma albumin, complement, remission rate and incidence of adverse reactions. Results(1)The clinical remission rate: The clinical remission rate in MMF group was higher than that in CTX group(P0.05);(2) Laboratory indicators: Two groups of patients after corresponding treatment, patients' urine protein quantity decreased than before treatment,and plasma albumin and the number of complement in the rising stage, the ANA positive rate difference(MMF group χ2=25.647,CTX group χ2=14.587) had statistical significance(P0.01); And MMF group compared to CTX group after treatment was statistically significant difference(P0.05);(3)The adverse reactions: Drug adverse reaction in MMF group was lower than that in CTX group(P0.01). Conclusion Curative effect of MMF combined with prednisone treating refractory LN is more distinct,less adverse reaction,better than CTX combined with prednisone.