Application of serum Cys C,NAG in clinical significance of early diabetic nephropathy

Objective To investgate the clinical significance of eystatin C(Cys C),N-acetyl-D-glucosaminidase(NAG) in the damage degree of diabetic nephropathy.Methods 113 cases with type 2 diabets admitted into the hospital were enrolled into the retrospective study,they are divided into three groups according to UAER levels,including diabetes mellitus without albuminiria,microalbuminiria and macroalbuminiria.Common characters were recorded such as sex,age,smoke status.All subjects were measured Urinary albumin rate,N-acetyl-D-glucosaminidase(NAG),Glomerular filtration rate(GFR).Results(1) The level of eystatin C,NAG increase along with the aggravation of the disease;The level of eystatin C,NAG are higer in microalbuminiria goup and macroalbuminiria group than that of diabetes mellitus without albuminiria group;The level of eystatin C,NAG are much higer in macroalbuminiria group than that of microalbuminiria goup;(2) There was a positive correlation with eystatin C and Serum creatinine(Scr),Urinary albumin rate,Schwartz was 0.741,0.617(P0.01),there was a negative correlation between eystatin C and Glomerular filtration rate(GFR),and Schwartz was-0.606(P0.01),The correlation between NAG and Serum creatinine(Scr),Urinary albumin rate,GFR was 0.558,0.617,-0.524(P0.01);(3) The study showed AUCROC of eystatin C is larger than that of Scr,and similar to that of UAER.Conclusion Cystatin C,NAG could be used to as sensitive indicator for diagnose the damage in kidney of diabetes.