The significance of CysC,β_2-MG and urinary NAG in early renal damage of patients with diabetes

Objective To evaluate serum cystatin C(CysC),urinary β2-microglobulin(β2-MG) and urinary N-acetyl-β-D-glucosaminidase(NAG) in early renal damage of patients with type 2 diabetes mellitus.Methods We used immunoturbidimetry to test urine microalbumin,and urine NAG was tested by colorimetric method,serum CysC and urineβ2-MG were measured by latex enhanced nephelometric method.According to urine albumin excretion rate(UAER),71 patients with type 2 diabetes mellitus were divided into two groups,normal UAER group and microalbuminuria group,and the healthy people were as the control group(n=35),then we compared the results among groups.Results We compared the result of UAER normal group and control group,and the CysC level increased,with the positive rate of 28.5%,but there was no significant difference of the β2-MG,NAG between the two groups.Compared with the control group,the positive rates of CysC,β2-MG,NAG in albumin group were 88.5%,80.0% and 65.7%,respectively,with significant difference.Conclusion Serum CysC,β2-MG and urinary NAG may reflect early renal damage,and the levels of them has a positive correlation with the degree of renal injury.With the joint detection,we can improve the early detection rate of renal injury in patients with diabetes.