Topical Photodynamic Therapy with 5 Aminolevulinic Acid for Cervical Condyloma Acuminatum

Objective To explore the proper concentration of 5-aminolevulinic acid-photodynamic therapy( ALA-PDT)for cervical condyloma acuminatum. Methods All of the ninety-five patients were randomly divided into 3groups: 10% ALA,20% ALA and 30% ALA. All of three groups was given 10%,20%,30% ALA thermal gel followed by PDT,respectively. The interval of 7 ~ 10 days was appropriate for the therapy. After three times' treatment the curative effect of clinic was observed. After the end of the therapy for three groups,patients were followed up for 3 months. Results The ratio of resolution of the lesions was 90. 00%( 27 /30) in patients with cervical condyloma acuminatum treated by 10% ALA-PDT through 3 times. The overall recurrence rate was 33. 33%( 10 /30). Complete remission of HPV was 20. 00%( 6 /30) in patients. The ratio of resolution of the lesions was 97. 14%( 34 /35) in patients with cervical condyloma acuminatum treated by 20%ALA-PDT through 3 times. The overall recurrence rate was 14. 29%( 5 /35). Complete remission of HPV was54. 29%( 19 /35) in patients. The ratio of resolution of the lesions was 100. 00%( 30 /30) in patients with cervical condyloma acuminatum treated by 30% ALA-PDT through 3 times. The overall recurrence rate was6. 67%( 2 /30). Complete remission of HPV was 73. 33%( 22 /30) in patients. These results show significant difference among the ratio of resolution of the lesions,the overall recurrence rate and the complete remission of HPV in the three different groups. Almost all the patients in ALA-PDT group presented pain during illumination. but no severe side effects or scar formation was observed. Conclusion The 30 percent of ALA-PDT may serve as a therapeutic option for cervical condyloma acuminatum.