Value of comprehensive diagnosis with clinical history,X-ray mammography and MRI for granulomatous mastitis

Objective:To explore the value of the combination of clinical history,X-ray mammography and breast MRI in the diagnosis of granulomatous mastitis.Methods:635cases of granulomatous mastitis underwent breast MRI and X-ray mammography in two weeks before surgery,including 14 patients with pathologically confirmed granulomatous mastitis.The sensitivity,specificity,misdiagnosis rate,positive predictive value and negative predictive value of using mammography only,using MRI only and using the combination of three examinations(clinical findings,mammography and MRI)for diagnosis of granulomatous mastitis were analyzed.Results:The sensitivity of X-ray mammography,MRI and three combined examinations to diagnose granulomatous mastitis was 14.3%,71.4%,85.7% respectively;specificity was 98.6%,99.2%,99.5%;rate of missed diagnosis was 85.7%,28.6%,14.3%;positive predictive value were 18.2%,66.7%,80%;negative predictive value was 98.1%,99.4%,99.7%.The sensitivity,specificity,positive predictive value and negative predictive value of three combined examinations to diagnose granulomatous mastitis was significantly increased(Pvalues were 0.00,0.00,0.01,0.01),while misdiagnosis rate was significantly decreased(P=0.00).Conclusion:The combination of clinical history,X-ray mammography and MRI can improve the diagnosis of granulomatous mastitis.