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2008•Acta Academiae Medicinae WeifangRequires access

Significance of Expression of IL-8 and TNF in Herniation of Intervertebral Disc

Ming Wen

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Abstract

Objective To explore the mechanism of interleukin-8(IL-8) and tumor necrosis factor(TNF) in the lumbar disc herniation in flammation reaction.Methods The medium was analyzed subsequently for the production of interleukin-8 and tumor necrosis factor in the normal group and herniation group.Results IL-8 and TNF were detected in all herniated specimens and the concentration is at a high level and different among the three herniated groups.Yet at the normal group the concentration of IL-8 and TNF low sharply or nothing at all.Conclusion Both IL-8 and TNF can be produced by the herniated intervertebral disc itself.TNF and IL-8 have a low concentration at the early stage yet increase gradually as the herniation degree increase,and then a series of biochemical changes.This will quicken the resorption of herniated intervertebral disc.

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What this paper is about

Objective To explore the mechanism of interleukin-8(IL-8) and tumor necrosis factor(TNF) in the lumbar disc herniation in flammation reaction.Methods The medium was analyzed subsequently for the production of interleukin-8 and tumor necrosis factor in the normal group and herniation group.Results IL-8 and TNF were detected in all herniated specimens and the concentration is at a high level and different among the three herniated groups.Yet at the normal group the concentration of IL-8 and TNF low sharply or nothing at all.Conclusion Both IL-8 and TNF can be produced by the herniated intervertebral disc itself.TNF and IL-8 have a low concentration at the early stage yet increase gradually as the herniation degree increase,and then a series of biochemical changes.This will quicken the resorption of herniated intervertebral disc.

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Available abstract

Objective To explore the mechanism of interleukin-8(IL-8) and tumor necrosis factor(TNF) in the lumbar disc herniation in flammation reaction.Methods The medium was analyzed subsequently for the production of interleukin-8 and tumor necrosis factor in the normal group and herniation group.Results IL-8 and TNF were detected in all herniated specimens and the concentration is at a high level and different among the three herniated groups.Yet at the normal group the concentration of IL-8 and TNF low sharply or nothing at all.Conclusion Both IL-8 and TNF can be produced by the herniated intervertebral disc itself.TNF and IL-8 have a low concentration at the early stage yet increase gradually as the herniation degree increase,and then a series of biochemical changes.This will quicken the resorption of herniated intervertebral disc.

Key concepts: Tumor necrosis factor alpha, Intervertebral disc, Medicine, Tumor necrosis factor α, Resorption, Disc herniation, Interleukin, Internal medicine

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Significance of Expression of IL-8 and TNF in Herniation of Intervertebral Disc — Research Paper | ScholarLens