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2011•Nanjing Zhongyiyao Daxue xuebaoRequires access

Effects of Curcumin on Growth of Human Ovary Cancer Cell Line skov3

Sumei Zhang

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Abstract

OBJECTIVE To explore the effects of curcumin(CCM) on the cell proliferation,morphology and the vitro growth of human ovary cell line skov3.METHODS Growth inhibition rate of skov3 cells was measured with MTT method.Morphological changes of cells were observed by fluorescent microscope and invert microscope.Apoptotic rate of the cells was inspected by flow cytometery(FCM).RESULTS CCM induced the apoptosis of the human ovary cancer cell line skov3 in a dose-and time-dependent manner.Some apoptotic cells resulted in morphological changes.CONCLUSION CCM significantly inhibits the vitro growth of ovary cancer cells skov3.

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OBJECTIVE To explore the effects of curcumin(CCM) on the cell proliferation,morphology and the vitro growth of human ovary cell line skov3.METHODS Growth inhibition rate of skov3 cells was measured with MTT method.Morphological changes of cells were observed by fluorescent microscope and invert microscope.Apoptotic rate of the cells was inspected by flow cytometery(FCM).RESULTS CCM induced the apoptosis of the human ovary cancer cell line skov3 in a dose-and time-dependent manner.Some apoptotic cells resulted in morphological changes.CONCLUSION CCM significantly inhibits the vitro growth of ovary cancer cells skov3.

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Available abstract

OBJECTIVE To explore the effects of curcumin(CCM) on the cell proliferation,morphology and the vitro growth of human ovary cell line skov3.METHODS Growth inhibition rate of skov3 cells was measured with MTT method.Morphological changes of cells were observed by fluorescent microscope and invert microscope.Apoptotic rate of the cells was inspected by flow cytometery(FCM).RESULTS CCM induced the apoptosis of the human ovary cancer cell line skov3 in a dose-and time-dependent manner.Some apoptotic cells resulted in morphological changes.CONCLUSION CCM significantly inhibits the vitro growth of ovary cancer cells skov3.

Key concepts: Ovary, Curcumin, Apoptosis, In vitro, Fluorescence microscope, Cell growth, Cell biology, Cell culture

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