Comparison of the pharmacokinetics between the two injections of nimodipine in beagle

OBJECTIVE To investigate the pharmacokinetics properties and bioequiavailence of two dosage forms of nimodipine(NM) in dogs.METHODS Single dose of NM was given to beagles in an open randomized cross-over design to study the pharmacokinetic parameters of NM.NM concentrations in plasma were determined by HPLC.RESULTS The pharmacokinetic parameters of NM emulsion for injection and injection were as follows: AUC_(0-5 h)((355.8)±(114.6)),((338.9)±(83.0)) h·μg·L~(-1),AUC_(0-∞)((356.8)±(114.5)),((339.9)±(82.9)) h·μg·L~(-1),t_(1/2α)((0.32)±(0.19)),((0.27)±(0.17)) h,t_(1/2β)((1.57)±(0.48)),((1.46)±(0.27)) h,respectively.The statistical analysis results showed that there was no significant difference between the two formulations.The relative bioavailability of the test formulation was((103.7)±(11.2))%.CONCLUSION The two formulations were bioequivalent and the emulsion for injection was superior to the injection in safety.