Effect of Shouwuyizhiling on SOD activity,MDA content in brain tissue of vascular dementia model rats

Objective To observe the effect of Shouwuyizhiling on SOD activity and MDA content in brain tissue of vascular dementia(VD) model rats and discuss its mechanism.Methods The VD model rats were established with modified 4-VO method.All the expermental rats were divided into Shouwuyiahiling,piracetam,model and sham operation groups.SOD activity and MDA content in brain tissue of rats in defferent groups were determined after a period time of intervention.Results After twenty days of intragastric administration, SOD activity in brain tissue of VD model rats of Shouwuyizhiling group was sifnificantly enhanced,and MDA content was significantly reduced,which were remarkbly different from those of piracetam group and model group(P0.05,P0.01).Conclusions Shouwuyizhiling can enhance SOD activity and reduce MDA content in brain tissue of VD model rats,this may be the main mechanism of its intervention on VD.