The relationship between the levels of serum high-sensitivity C-reactive protein and lipids in pilots

Objective To investigate the relationship between blood levels of high-sensitivity C-reactive protein (Hs-CRP) and lipids in pilots, so as to provide evidence for control of cardiovascular disease. Methods The method of measuring the levels of blood Hs-CRP in the laboratory were established, the levels of blood lipids and Hs-CRP in 200 pilots and 100 ground personnel with matched age were detected. The relationship between the levels of blood lipids and Hs-CRP were studied. Results The difference between blood Hs-CRP levels in pilots and that in ground personnel was nonsignificant. In pilots with hyperlipidemia along with the increase of TG and LDL, the concentration of Hs-CRP was increased significantly ( P 0.01), the level of TG closely correlated with Hs-CRP level ( r=0.998,P 0.05). Multivariate linear regression analysis showed that blood TG level was the significant factor influencing the level of Hs-CRP ( P 0.05). Conclusion It is suggested that blood lipids may play an important role in the release of Hs-CRP. Because the elevated serum TG and LDL can induce increase of Hs-CRP level, more attention should be paid to pilots with hyperlipidemia so that atherosclerosis and coronary heart disease can be prevented and decreased.