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2014•Journal of reproductive medicineRequires access

Efficacy and safety of letrozole in ovulation induction

Xiaohan Xu

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Abstract

Letrozole,an aromatase inhibitor,was firstly introduced as a potential ovulation induction agent in 2 000,followed by a large number of studies published.Letrozole appears to be a good option,with its convenient administration route,reliability,single follicle development,negligible anti-estrogen effect and decreased dose of gonadotropin used.It has been used for ovulation induction in patients with polycystic ovary syndrome(PCOS),intrauterine insemination,various protocols of in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)and fertility preservation.Furthermore,letrozole was applied in the adjuvant treatment of breast cancer originally.This review focuses on the efficacy and safety of letrozole in ovulation induction.

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What this paper is about

Letrozole,an aromatase inhibitor,was firstly introduced as a potential ovulation induction agent in 2 000,followed by a large number of studies published.Letrozole appears to be a good option,with its convenient administration route,reliability,single follicle development,negligible anti-estrogen effect and decreased dose of gonadotropin used.It has been used for ovulation induction in patients with polycystic ovary syndrome(PCOS),intrauterine insemination,various protocols of in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)and fertility preservation.Furthermore,letrozole was applied in the adjuvant treatment of breast cancer originally.This review focuses on the efficacy and safety of letrozole in ovulation induction.

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Available abstract

Letrozole,an aromatase inhibitor,was firstly introduced as a potential ovulation induction agent in 2 000,followed by a large number of studies published.Letrozole appears to be a good option,with its convenient administration route,reliability,single follicle development,negligible anti-estrogen effect and decreased dose of gonadotropin used.It has been used for ovulation induction in patients with polycystic ovary syndrome(PCOS),intrauterine insemination,various protocols of in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)and fertility preservation.Furthermore,letrozole was applied in the adjuvant treatment of breast cancer originally.This review focuses on the efficacy and safety of letrozole in ovulation induction.

Key concepts: Letrozole, Ovulation induction, Medicine, Aromatase inhibitor, Intracytoplasmic sperm injection, Ovulation, Polycystic ovary, Gynecology

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