Study on Degradation Kinetics of Amorolfine Hydrochloride in Aqueous Solution

Objective:To study the degradation kinetics of amorolfine hydrochloride in aqueous solution.Methods:A HPLC method was established to measure the degradation kinetic parameters of amorolfine hydrochloride in PBS solutions with various pH values and ionic strengths at different temperatures.Results:Degradation of amorolfine hydrochloride in aqueous solution followed the pseudo-first order kinetics and the degradation rate increased with the increase of temperature.At 37 and 60 ℃.The degradation rate of amorolfine hydrochloride increased (P0.05) and its half-time and expiration date decreased (P0.05) significantly with the increase of pH value,but the degradation rate decreased with the increase of ionic strength(P0.05).Amorolfine hydrochloride was relatively stable at the low temperature and the activation energy of its degradation increased with the increase of pH value.Conclusion:Degradation rate of amorolfine hydrochloride in aqueous solution is related with temperature,pH and ionic strength.