Clinical value of AAR and API in evaluating liver fibrosis of chronic hepatitis B

Objective To compare the clinical value of AAR and API in evaluating liver fibrosis of chronic hepatitis B.Methods There were 172 patients with chronic hepatitis B who were underwent liver biopsy with their liver function and blood routine taken simultaneously.Three different endpoints were studied according to liver fibrosis stages,namely without/light fibrosis(S0/S1),significant fibrosis(S2/S3/S4) and cirrhosis(S4).The area under the receiver operating characteristic(ROC) curve(AUC) reflected its diagnostic value.Results There was no significant difference in AAR of fibrosis S0,S1,S2,S3 and S4(P0.05).The correlation coefficient between liver fibrosis stages and AAR was 0.107(P0.05).The AUC of AAR with significant fibrosis /cirrhosis was low to 0.7.The API of fibrosis S4 was higher than those of fibrosis S0,S1,S2 and S3(P0.01).The correlation coefficient between liver fibrosis stages and API was 0.314(P0.01).The AUC of API with cirrhosis attached 0.773(P0.01).However,that of significant fibrosis was low to 0.7(P0.05).Conclusion There is little clinical value with AAR in evaluating liver fibrosis of chronic hepatitis B.There is definite correlation between liver fibrosis stages and API.API can be used for diagnosis of fibrosis S4.However,it can not discriminate fibrosis S1,S2 and S3.