Clinical value of Bonacini's cirrhosis discriminant score to the diagnosis of liver fibrosis in chronic virus hepatitis B

Objective To testify the clinical value of cirrhosis discriminant score to the diagnosis of liver fibrosis in chronic virus hepatitis B.Methods One hundred and seventy-two patients with chronic virus hepatitis B underwent liver biopsy and their liver function,blood routine and blood clotting function were detected simultaneously.Three different endpoints were studied according to liver fibrosis stage,namely significant fibrosis(S2/S3/S4),extensive fibrosis(S3/S4) and cirrhosis(S4).The AUC reflected its diagnostic values.Results The cirrhosis discriminant score of S4 was higher than those of S0,S1,S2 and S3(P0.01).The correlation coefficient between liver fibrosis stage and cirrhosis discriminant score was 0.375(P0.01).The AUC for significant fibrosis,extensive fibrosis and cirrhosis were 0.726,0.626 and 0.814,respectively.The positive predictive value for significant fibrosis was 95.3%.The negative predictive value for cirrhosis was 96.5%.The sensitivity for extensive fibrosis was 38.8%.Conclusion There is correlation between liver fibrosis stage and cirrhosis discriminant score.Cirrhosis discriminant score can evaluate significant fibrosis and cirrhosis in patients with chronic virus hepatitis B,however,it can not discriminate fibrosis S2 and S3.