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2006•Chemical ResearchRequires access

Determination of Isosorbide-5-mononitrate in Rats Plasma by HPLC-MS

Shanmao Li

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Abstract

A method for determination of isosorbide-5-mononitrate in rats plasma by HPLC-MS was developed.An Agilent MSD equipped with an APCI source was used as detector and was operated in negative ion mode.The linear range is 0.034 64~103.0 mg/L,the recovery is 93.1 %~112 %,the RSD is less than 6 %.The method is convenient,accurate,and can be used for therapeutic monitoring and pharmacokinetics study.

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A method for determination of isosorbide-5-mononitrate in rats plasma by HPLC-MS was developed.An Agilent MSD equipped with an APCI source was used as detector and was operated in negative ion mode.The linear range is 0.034 64~103.0 mg/L,the recovery is 93.1 %~112 %,the RSD is less than 6 %.The method is convenient,accurate,and can be used for therapeutic monitoring and pharmacokinetics study.

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Available abstract

A method for determination of isosorbide-5-mononitrate in rats plasma by HPLC-MS was developed.An Agilent MSD equipped with an APCI source was used as detector and was operated in negative ion mode.The linear range is 0.034 64~103.0 mg/L,the recovery is 93.1 %~112 %,the RSD is less than 6 %.The method is convenient,accurate,and can be used for therapeutic monitoring and pharmacokinetics study.

Key concepts: Chromatography, Pharmacokinetics, Chemistry, High-performance liquid chromatography, Isosorbide mononitrate, Plasma concentration, Pharmacology, Medicine

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