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2002•Journal of Pediatric PharmacyRequires access

Determination of 5-isosorbide mononitrate and their pharmacokinetics in healthy volunteers by GC-ECD

Rong Li

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Abstract

Objective:To establish a gas chromatograph with electron captured detector (GC ECD) assay for the determination of 5 isosorbide mononitrate (5 IM) in human plasma Methods:The plasma levels of 5 IM was analyzed by capillary gas chromatograph with 63 Ni electron captured detector,2 nitro benzene chloride served as the internal standard for quantitation Results:There were good liner correlation in the range of 5 IM 8～800 μg/L (r=0 9945) The extracted recovery was more than 97% and RSD of inter day and intra day were less than 5% Conclusions:The method is simple,accurate and can be used to determine the concentration of 5 IM

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What this paper is about

Objective:To establish a gas chromatograph with electron captured detector (GC ECD) assay for the determination of 5 isosorbide mononitrate (5 IM) in human plasma Methods:The plasma levels of 5 IM was analyzed by capillary gas chromatograph with 63 Ni electron captured detector,2 nitro benzene chloride served as the internal standard for quantitation Results:There were good liner correlation in the range of 5 IM 8～800 μg/L (r=0 9945) The extracted recovery was more than 97% and RSD of inter day and intra day were less than 5% Conclusions:The method is simple,accurate and can be used to determine the concentration of 5 IM

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Available abstract

Objective:To establish a gas chromatograph with electron captured detector (GC ECD) assay for the determination of 5 isosorbide mononitrate (5 IM) in human plasma Methods:The plasma levels of 5 IM was analyzed by capillary gas chromatograph with 63 Ni electron captured detector,2 nitro benzene chloride served as the internal standard for quantitation Results:There were good liner correlation in the range of 5 IM 8～800 μg/L (r=0 9945) The extracted recovery was more than 97% and RSD of inter day and intra day were less than 5% Conclusions:The method is simple,accurate and can be used to determine the concentration of 5 IM

Key concepts: Electron capture detector, Chromatography, Gas chromatography, Capillary gas chromatography, Benzene, Pharmacokinetics, Chemistry, Medicine

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