A comparative study of escitalopram combined with cognitive therapy in the treatment of alcohol dependent patients with depression disorder

Objective To explore the clinical efficacy and safety of escitalopram combined with cognitive therapy in the treatment of alcohol dependent patients with depression disorder.Methods 62 alcohol dependence patients with depression disorder were randomly assigned to the treatment groups for escitalopram combined with cognitive therapy(research group) or single escitalopram(contrast group) treatment for 8 weeks.The curative effects and adverse reactions were assessed with the Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA),Clinical general impression(CGI) and treatment emergent symptom scale(TESS) respectively at baseline and 1,2,4,8week.Results The scores of HAMD,HAMA and CGI are significantly lower after 2,4,8weeks treatment in both groups(P 0.01).The significant improvement were found in the research group at the end of first week treatment(P 0.01),which suggest that the research group took effects faster.The scores of HAMD,HAMA and CGI in the research group are significant than the contrast group after 1,2,4,8weeks treatment(P 0.05 or P 0.01),the research group decreased more significantly.Effective rate of the research group was 93.55% and of the contrast group was 74.20%,the difference was significant(P 0.05).The side effects were no significant between two groups(P 0.05).Conclusion Escitalopram combined with cognitive therapy can increase curative effect and shorten the period of treatment.