Clinical Investigation on the Effect of Integrative Traditional Chinese and Western Medicine in Treating Incipient Chronic Renal Insufficiency Caused by Diabetic Nephropathy

Objective To investigate the clinical effect of Integrative Traditional Chinese and Western Medicine(ITC-WM)in treating incipient chronic renal insufficiency caused by diabetic nephropathy.Methods The patients with incipient chronic renal insufficiency caused by diabetic nephropathy(DN)were randomly divided into ITC-WM group and control group treated alone with Western Medicine(WM).The variations in clinical symptoms,plasma lipids,renal function,urinary protein content in 24 hours between two groups were observed before and after the treatment.Results The effective rate in ITC-WM group was 75.0% compared with 61.9% in WM group(P0.01).Renal function and urinary protein contents in 24 hours in both groups were notably reduced after 3 months(P0.05 or P0.01).However,the above parameters in ITC-WM group were lower than those in WM group 3 months later(P0.05 or P0.01).The clinical symptoms in both groups showed significant improvement after 3 months(P0.05 or P0.01)but they were improved in ITC-WM group in comparison with those in WM group(P0.05).And plasma lipid disturbances in ITC-WM group were improved after 3 months compared with those in WM group(P0.05).Conclusion It is suggested that integrative therapy with Traditional Chinese and Western Medicine is more effective than simple therapy with Western Medicine in treating patients with incipient chronic renal insufficiency caused by diabetic nephropathy.