Expression and clinical significances of Survivin and p53 in non-small cell lung cancer

OBJECTIVE:To investigate the function of Survivin and p53 in non-small cell lung cancer(NSCLC).METHODS: The expression of Survivin and p53 was evaluated in 60 specimens of NSCLC and 10 specimens benign lung tissues by immunohistochemistry SP method.RESULTS: The positive rate of Survivin in lung cancer(61.6%) was significantly higher than that of Survivin in benign tissues(0,χ2=13.08,P=0.000).The positive rate of Survivin in clinical stage Ⅲ-Ⅳ lung cancer(77.1%) was significantly higher than that stage ofⅠ-Ⅱ(40.0%),χ2=8.511,P=0.004.The positive rate of p53 in NSCLC(56.7%),was significantly higher than that of p53 in benign tissues(0,χ2=11.02,P=0.001).The positive rate of p53 in clinical stage Ⅲ-Ⅳ NSCLC(71.4%) was significantly higher than that stage of Ⅰ-Ⅱ(36.0%,χ2=7.454,P=0.006).Neighter Survivin nor p53 was correlated with sex,age and pathology types(P0.05).CONCLUSION: The Survivin and mutant p53 gene may participate in lung carcinogenesis and development of lung cancer,and it can be identified as a marker to diagnosis and evaluate prognosis of lung cancinoma.