The Experimental Study of BMSCs Transplanted Into Rat Models of Liver Cirrhosis

Objective: To evaluate the clinical effects of bone marrow mesenchymal stem cells used in liver cirrhosis rats and collect data for the clinical trials.Methods: Liver cirrhosis rat models were prepared and then divided randomly into two groups,experimental group and control group,25 in each group.The BMSCs were transplanted into rats' liver of experimental group.After surgery,all the rats were still intraperitoneally injected with 40% CCl4 solution in a dose of 0.5mL/100g.After three weeks,animals were sacrificed.Venous blood was collected to test the indexes such as ALT,TBIL,ALB and AFP,and rats' liver were for pathological observation.Results: Dif-ferentiated liver cells could be observed in experimental group.Three rats died in experimental group and two in control group.There were significant differences in ALT,ALB,TBIL and AFP between two groups,P0.05.However,the AST of two groups hasn't signifi-cant difference.Conclusion: BMSCs injected into rat models of liver cirrhosis can greatly improve liver function and also give a guide to clinical trials.