The Study the Expression of TGF-α in Liver Cirrhosis Rat Liver after Partial Hepatectomy

Objective To study the expression of TGF-α in liver cirrhosis rat liver after partial hepatectomy.Methods 80 adult male Wistar rats were selected and randomly divided into two groups,40 0f the experimental group were made rat liver cirrhosis models.Then,all the rats were removed the left and middle liver lobe.And divided each group into 8 groups,the first group were killed at once,other groups were killed in 12h、24h、2d、4d、8d、14d、 20d after the surgery.Immunohistochemistry was used to detect TGF-α expression in hepatocytes.Results Successful models with the liver cirrhosis.The ratio of liver partial hepatectomy was 75.23±2.4(%).After liver partial hepatectomy,the expression of TGF-α in liver cirrhosis rats was lower than normal rats.Conclusion the After liver damage can secrete TGF-α for regeneration,the expression in liver cirrhosis compared with normal liver delay,also ability to promote regeneration of liver cells was weaker than normal ones.