Expression of fragile histidine triad in colon carcinoma tissue and its relationship with biological behaviour of patients

Objective To discuss expression of fragile histidine triad(FHIT) in colon carcinoma tissue and its relationship with biological behaviour of patients. Methods From January 2008 to July 2013, the First Hospital of Taizhou City, 80 cases of colon carcinoma were selected as cases group, 25 cases of normal colon tissues near the tumor(5 cm from the tumor edge) were additionally selected as control group. The expression of FHIT protein in tissues were detected by immunohistochemical S-P method, and the FHIT protein expression and its relationship with biological behaviour of patients was analyzed as well. Results The positive expression rate of FHIT in 80 cases of colon carcinoma tissues in case group was 45.0%(36/80). The FHIT protein expression rate of 25 cases of normal colon tissues near the tumor in control group was 72.0%(18/25). The positive rate of FHIT in the colon carcinoma tissue in cases group was much lower than that in normal colon tissue of control group, the difference was statistically significant(P 0.05). The FHIT expression levels of the colon carcinoma tissue in cases group were compared between different histological grade, the differences were not statistically significant(P 0.05). With the extent of infiltrating depth of primary lesion, lymphatic metastasis and distant metastasis rising, the FHIT expression levels showed inclining to decline(P 0.05 or P 0.01). Conclusion FHIT has close relationship with the occurrence, development, infiltration, metastasis and prognosis. As the development of infiltration and metastasis of colon carcinoma, FHIT protein expression shows the obvious declining and shortage status. FHIT genes might be the new target spot of diagnosis and treatment of colon carcinoma genes.