2011•Zhongguo shiyan fangjixue zazhiRequires access

Pharmacokinetics of Salidroside Liposomes in Rats

GU Gang-mei

Abstract

Objective:To study the pharmacokinetics of salidroside liposomes in rats.Method:SD rats were divided into control group with salidroside solution and experimental group with liposomes.Plasma concentrations of salidroside in rats after intragastric administration were determined by HPLC.The pharmacokinetics parameters were calculated by DAS2.0.Result: The main pharmacokinetic parameters of liposomes and solution of salidroside were as the followings:t1/2β were(13.19 ± 0.60),(5.16 ± 0.19)h;AUC0-12were(4.75 ± 0.69) and(2.68 ± 0.74) μg.mL-1.h-1.Conclusion: Salidroside liposomes could release the drug slowly.

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Key concepts: Salidroside, Pharmacokinetics, Liposome, Pharmacology, Chemistry, Chromatography, High-performance liquid chromatography, Medicine