2011•Chinese Journal of New Drugs and Clinical RemediesRequires access

Pharmacokinetics of dl-praeruptorin A liposomes in rats by LC-MS/MS method

Xuan Zhu

Abstract

AIM To study the pharmacokinetics of dl-praeruptorin A liposomes in rats by LC-MS/MS method.METHODS dl-Praeruptorin A liposomes was obtained by the ethanol injection method.Pharmacokinetic parameters were determined after intravenous administration of dl-praeruptorin A liposomes(5,10 and 20 mg·kg~(-1)) and dl-praeruptorin A solution(control solution,10 mg·kg~(-1)) in rats.RESULTS The drug content was 2 g·L~(-1),encapsulation efficiency was 93.2%.The t_(1/2) of dl-praeruptorin A liposomes(5,10 and 20 mg·kg~(-1)) and control solution were(136.58±22.86),(74.12±6.97),(44.93±7.47),(51.26±5.13) min,AUC_(0-∞) were (215.93±33.24),(91.75±26.47),(29.22±4.47),(66.90±14.54) min·mg·L~(-1) respectively. CONCLUSION dl-praeruptorin A liposomes can increase the bioavailability and has a long half-life in rats.

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Key concepts: Pharmacokinetics, Liposome, Bioavailability, Chromatography, Chemistry, Pharmacology, Ethanol, Medicine