Distribution and drug resistance of Enterobacter cloacae

Objective To understand the clinical distribution of resistance of Enterobacter cloacae(ECL)in hospital and provide foundation for clinical use of antibiotics.Methods The drug susceptibility and extended spectrum β-lactamase(ESBLs)of 55 Enterobacter cloacae strains detected from April 2010 to August 2011 were determined.The drug susceptibility of Enterobacter cloacae was tested by using disc diffusion method(K-B).The ESBLs-producing strains were confirmed by double disk synergy test.Results 49.0% of the 55 Enterobacter colacae strains in clinical specimens were in the sputum specimen of ICU,urinary surgery and respiratory departments.The strains were still susceptible to meropenem and imipenem and the resistan rate to cefoperazone/sulbactam was 7.27%.The resistant rates to cefotaxime,ampicillin and cefazolin were 80.0%,100% and 100%respectively.The resistant rates of positive ESBLs strains to cefotaxime,cefepime,ceftazidime,gentamicin and cefoxitin were higher than those negative ESBLs strains,showing statistically significant difference(P0.05).The rates of drug resistance of positive strains of ESBLs and negative strains of ESBLs to cefoperazone/sulbactam,amikacin,piperacillin/tazobactam and ciprofloxacin were not staistically different.Conclusion The monitoring of Enterobacter cloacae,ESBLs-positive strain in particular,should be strengthened and clinical use of antibiotics be based on susceptiblity test results.