Analysis the distribution and the drug resistance of clinical infection due to Enterobacter cloacae

Objective To investigate the clinical distribution and the drug resistance of Enterobacter cloacae in North Sichuan Area.Methods Retrospective study the clinical distribution of isolated 59 Enterobacter cloacae.Agar dilution medthod was used for drug sensitivity test,the phenotypes of Enterobacter cloacae strains harboring AmpC β-lactamases(AmpC)and extended-spectrum β-lactamases(ESBLs)were detected by modified three-dimensional extract test.The results of sensitive,intermediary,tolerance were evaluated according to the Clinical Laborarory Standarads Institute(CSLI)of released in 2006.Results 59 Enterobacter cloacae were especially common the specimens in sputum,urine,intensive care unit(ICU)and respiratory medicine.But for showing the lowest resistant rate to imipenem(3.39%),the resistant rates to the other 11 types antibacterial agents were more than 20%.ESBLs and AmpC were carryed on a total of 34 strains of Enterobacter cloacae.AmpC β-lactamases,AmpC β-lactamases combined with ESBLs and ESBLs producing strains were detected in 30.5%,8.47% and 18.65% of Enterobacter cloacae respectively,the relevance ratio of ESBLs positive strains was 38.98%.The great height resistant rate to 11 types antibacterial agents except imipenem were showed in ESBLs positive strains(44.45%～100%).Conclusion Enterobacter cloacae often induces respiratory tract infection and urinary tract infection and the relevance ratio of ESBLs was very high and the multiple drug resistance was very serious in North Sichuan Area.