Anti-virus Therapy of Liver Cirrhosis after Chronic Hepatitis B in Patients with Adefovir Dipivoxil Resistance

Objective To investigate the therapeutic efficacies of anti-virus drugs on liver cirrhosis after chronic hepatitis B in patients with adefovir dipivoxil resistant.Methods Sixty-two of liver cirrhosis after chronic hepatitis B with adefovir dipivoxil resistant were randomly divided into two groups:32 patients in group Ⅰ were administrated with adefovir dipivoxil 10mg once a day and lamivudine 100 mg once a day for 2 years;30 patients in group Ⅱ were only taken entecavir 0.5 mg once a day for 2 years.Results The negative rate of HBV-DNA and HbeAg,and Child-Pugh score had not statistical difference between the two groups after 1 year and 2 years;there was statistically significance in Child-Pugh score of group Ⅰ before and after treatment,it was the same clinical status with group Ⅱ;the time of ALT recovery in group Ⅰ had significant difference from that in groupⅡ;As for the ALT recovery rate,there was no significant difference between the two groups.Conclusion Adefovir dipivoxil combined with lamivudine or only entecavir are effective and safe for the treatment of liver cirrhosis after chronic hepatitis B in patients with adefovir dipivoxil resistant.