Efficacy of adefovir dipivoxil combined with lamivudine on patients with hepatitis B related liver cirrhosis

Objective To investigate the efficacy of adefovir dipivoxil combined with lamivudine on patients with hepatitis B related liver cirrhosis. Methods Total of 52 cases with decompensated liver cirrhosis with HBV duplication were divided into two groups,randomly. The observation group was given adefovir dipivoxil combined with lamivudine and the control group was given adefovir dipivoxil only. Both groups were treated for 12,24 and 36 months,and the efficacy were compared. Results HBV DNA levels of patients in both groups after treatment decreased significantly compared with before treatment; but the effective rate of the observation group decreased more significantly than the control group,with significant difference ( P 0. 05) . After treated for 36 months,the effective rate of patients in the observation group was significantly higher than the control group ( P 0. 05) . Conclusions The efficacy of adefovir dipivoxil combined with lamivudine on hepatitis B related liver cirrhosis is effective,which could significantly improve the liver function and reduced HBV DNA level,and is a good treatment method for hepatitis B related liver cirrhosis.