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TOXICITY OF BISPHENOL A ON THE GROWTH OF ZEBRAFISH EMBRYOS

Zhenghua Duan, Lin Zhu

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Abstract

In order to evaluate the toxicity of the bisphenol A (BPA) on the growth of zebrafish embryos, fertilized eggs were exposed to the concentration of 2.00, 4.00, 6.00, 8.00, 10.00, 15.00, 18.00, 22.00 and 25.00mg/L BPA for 72h at 26±1℃. The results revealed that the sublethal toxicological endpoints induced by BPA were: delayed hatch＞ blood balk ＞ cyst＞ altered axial curvature and tail malformation. The median embryo lethal concentration (LC50) after 24h was 16.36mg/L. We concluded that the BPA toxicity on zebrafish embryos were caused before 8h exposure and it was not the result of long-term accumulation. Therefore, BPA maybe cause altered gene expression at the early stage of zebrafish embryos. In the further studies, we will use the technology of genetic chips to look for the toxic mechanism of BPA.

About this research paper

What this paper is about

In order to evaluate the toxicity of the bisphenol A (BPA) on the growth of zebrafish embryos, fertilized eggs were exposed to the concentration of 2.00, 4.00, 6.00, 8.00, 10.00, 15.00, 18.00, 22.00 and 25.00mg/L BPA for 72h at 26±1℃. The results revealed that the sublethal toxicological endpoints induced by BPA were: delayed hatch＞ blood balk ＞ cyst＞ altered axial curvature and tail malformation. The median embryo lethal concentration (LC50) after 24h was 16.36mg/L. We concluded that the BPA toxicity on zebrafish embryos were caused before 8h exposure and it was not the result of long-term accumulation. Therefore, BPA maybe cause altered gene expression at the early stage of zebrafish embryos. In the further studies, we will use the technology of genetic chips to look for the toxic mechanism of BPA.

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Available abstract

In order to evaluate the toxicity of the bisphenol A (BPA) on the growth of zebrafish embryos, fertilized eggs were exposed to the concentration of 2.00, 4.00, 6.00, 8.00, 10.00, 15.00, 18.00, 22.00 and 25.00mg/L BPA for 72h at 26±1℃. The results revealed that the sublethal toxicological endpoints induced by BPA were: delayed hatch＞ blood balk ＞ cyst＞ altered axial curvature and tail malformation. The median embryo lethal concentration (LC50) after 24h was 16.36mg/L. We concluded that the BPA toxicity on zebrafish embryos were caused before 8h exposure and it was not the result of long-term accumulation. Therefore, BPA maybe cause altered gene expression at the early stage of zebrafish embryos. In the further studies, we will use the technology of genetic chips to look for the toxic mechanism of BPA.

Key concepts: Zebrafish, Toxicity, Embryo, Andrology, Bisphenol A, Biology, Toxicology, Chemistry

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