Clinical observation on the application of combination of propofol-remifentani in painless gastroscopy

Objective To evaluate efficacy and safety of combination of propofol-remifentani in painless gastroscopy.Methods 200 patients with grade of ASA I～Ⅱundergoing gastroscopy were divided randomly into group PR(n=100) and group P(n=100).Patients in group P were infused propofol 1.5～2.5mg/kg intravenously;patients in group PR were infused propofol1～1.5mg/kg intravenously and pumped remifentani 0.15μg/(kg.min).Gastroscopy was inserted after eyelashes reflex had been extinct.Total dose of propofol,recovering time of consciousness and orientation,and occurrence of body movement and respiratory depression were observed and recorded.Results There was significant difference in respiratory depression and body movement during operation between the two groups(P0.05).The dosage of drug used in group P was obviously more than that in group PR(P0.05).Conclusions The combination of propofol with remifentani applied to the operation of gastroscopy can provide satisfactory anesthesia effects with advantage of lower dose of propofol,less respiratory depression and less body movement.