Clinical efficacy of Thalidomide combined VAD regimen in the treatment multiple myeloma

Objective To observe the clinical curative effect and toxicity of drugs of Thalidomide combined VAD regimen on treating newly diagnosed multiple myeloma (MM) patients.Methods 35 patients with newly diagnosed MM treated with Thalidomide combined VAD regimen.Every 21 days a course of treatment,intermittent 4 weeks after treatment,observation of efficacy and toxicity of drugs.Results After treatment for 3 treatments,among the 35 patients,5 patients achieved complete remission(CR)and 19 partial remission(PR),5 patients improved and the total effective rate was 82.8%.Drug toxicity were bone marrow suppression,fingertip numbness and constipation etc.Conclusion Treating newly diagnosed multiple myeloma (MM) patients with Thalidomide combined VAD regimen can obtain a better efficacy,which is effective,safe,well-tolerable and worth to practice in clinics.