2008•Letters in BiotechnologyRequires access
Preparation of Nanoparticles by Emulsion Solvent Evaporation Technique
Cheng Hong
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Abstract
Objective:To develop an emulsion solvent evaporation technique for the preparation of nanoparticles.Methods:The effects of different formulation and technics factors on the particle size,drug loading,and drug encapsulation efficiency were evaluated by single factor design and orthogonal design.Results:The nanoparticles prepared by emulsion solvent evaporation technique were round and uniform in size.The drug encapsulation efficiency of most preparations were more than 50%,and their particle size could be controlled.Conclusions:An emulsion solvent evaporation technique was optimized to manufacture nanoparticles meeting different requirement.