Myocardial integrated backscatter and left ventricular diastolic function in patients with type 2 diabetes mellitus

Objective To evaluate the changes of cardiac structure and function in patients with type 2 diabetes mellitus(DM).Methods Pulsed Doppler echocardiography (PDE), Doppler tissue imaging (DTI),and ultrasonic integrated backscatter (IBS) were examined in 40 patients with type 2 diabetes mellitus and 20 normal subjects.The following echocardiographic indices were investigated: the trans-mitral velocity, the pulmonary venous velocity, the mitral annulus velocity and the time averaged value of IBS , the calibrated time-averaged value of IBS (IBS%),and the magnitude of the cyclic variation of IBS (CVIB).Results (1) The indices of Ap,ap,and Va increased and the parameters of Ep/Ap,Ve, and Ve/Va decreased in diabetic patients (P(0.05)). (2) The IBS% of septum and left ventricular posterior wall was significantly higher and the CVIB was significantly lower in diabetic patients than in control group (P0.05).Conclusions (1)The diastolic dysfunction exists before the systolic function damage in patients with 2 type diabetes mellitus.(2) The assessment of mitral annulus velocity by DTI is a simple and more sensitive method than the other echocardiographic methods in evaluation of left ventricular diastolic dysfunction.(3) Ultrasonic integrated backscatter can be used as a means for early assessing myocardial histological changes in type 2 diabetes mellitus patients.