Clinical Stady on the Relation between Uric Acid and Insulin Resistance in Elderly Patients with Coronary Heart Disease

Objective To explore the relations between uric acid and insulin resistance in elderly patients with coronary heart disease(CHD).Methods Fasting plasma glucose,insulin,insulin sensitive index[ISI,Ln (1/fasting plasma glucose*fasting serum insulin)],uric acid,total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesteroi(LDL-C) were determined in138 patients with CHD and in 45 healthy control group.Results①Insulin and uric acid of CHD group were significanty higher than that in control group,ISI was obviously lower compared with that in control group.②When the patients with CHD were stratified by absence or presence of hyperuricemia,TG of patients with hyperuricemia was obviously higher than that in patients without hyperuricemia,HDL-C was obviously lower compared with that in control group.③There were negative correlation between uric acid and ISI in patients with CHD.Conclusion Elevation of serum uric acid in CHD is associated with insulin resistance.