COX-2 Expressionin Non-Small Cell Lung Cancer and Its Relationship with Clinical Pathology

Objective: To study the expression of cyclooxygenase-2(COX-2) in non-small cell lung cancer and para carcinoma tissues and its clinicopathological significance.Methods The expression of COX-2, by PV-9000immunohistochemistrical method in 80 cases of non-small cell lung cancer and 40 cases para carcinoma tissues.Results(1) COX-2 was expressed in tumor tissues and cancer side organizations, but positive expression of COX-2was significantly higher organized in the tissues of non-small cell lung cancer than in the cancer side organizations.Among them, COX-2's positive expression rate in non-small cell lung cancer was 88.75 %, while was 13.33% in the lung cancer side organizations.(2) The expression of COX-2 in non-small cell lung cancer had no significant difference between gender, local and histologic type(P0.05).The over expression of COX-2 was related with clinical pathologic parameters, such as tumor size, histologic grade, lymphatic metastasis and clinical staging(P0.05).Conclusions COX-2 express high existence in the tissues of non-small cell lung cancer, which show they were highly associated with theoccurrenceand developmentofthenon-smallcelllungcancer.