Effect of Natural Borneol on Pharmacokinetics of Nimodipine in Rats after Oral Administration

Objective: To study the effects of natural borneol( NB) on the pharmacokinetics of nimodipine in rats after oral administration. Method: The rats were randomly divided into three groups,control group,clinically-equivalent-dose group and higher-dose group,and were gavaged with NB at doses of 0,90,270mg·kg-1,respectively. After 10 min,all rats were gavaged with nimodipine at a dose of 20 mg·kg-1. The blood was obtained at different time points before and after the administration. Concentrations of nimodipine in plasma were determined by LC-MS-MS and the main pharmacokinetic parameters were calculated by WinNonlin5. 0. 1. Result: Clinically equivalent dose of NB showed little influence on the pharmacokinetics of nimodipine.The mean value of AUC in higher-dose group was slightly higher than that in control group,but no significant differences were found between two groups. Conclusion: The results suggested that higher dose of NB may enhance the absorption of nimodipine in rats,but the enhancing effect is not very obvious.