The bioavilability and pharmacokinetics study of pentoxifylline osmotic pump controlled release tablets in rabbits

Objective:To study the pharmacokinetics and relative bioavilability of pentoxifylline osmotic pump controlled release tablets in rabbits,and investigate its in vitro and in vivo correlation.Methods:Twelve rabbits were divided into two groups by double crossing method.The pentoxifylline in plasma was measured by HPLC.The relative bioavilability and pharmacokinetic parameters of pentoxifylline osmotic pump controlled release tablets were computed by 3P 87,and the correlation was studied by in vitro dissolution and in vivo pharmacokinetics with Wanger-Nelson method.Results:The pharmacokinetic parameters of test and reference preparation for pentoxifylline are:Tmax(3.41±0.7)and(1.36±0.26)h;Cmax(172.65±1.32)and(430.51±1.45)ng·mL-1;AUC0~∞(2264.74±3.1)and(2418.22±3.7)ng·h·mL-1,respectively.Conclusion:Pentoxifylline osmotic pump controlled release tablets have marked controlled-release characters.The Pentoxifylline osmotic pump controlled release tablets and the PTX tablets are bioequivalent.