2004•PubMedRequires access

[Expression of cyclooxygenase-2 and p53 and their correlation in carcinoma of larynx].

Haitao Lu, Shusheng Gong

Abstract

OBJECTIVE: To study the expression of cyclooxygenase-2 in laryngeal squamous carcinoma and evaluate the relation between cyclooxygenase-2 and p53. METHOD: The pathological sections of laryngeal squamous carcinoma was examined by using the method of immunohistochemistry. RESULT: Overexpression of Cox-2 and p53 were found in the laryngeal squamous carcinoma specimens; the positive rates of cyclooxygenase-2 and p53 protein expression were 58.7% (37/63) and 63.5% (40/63), respectively. The positive expressions of Cox-2 were related to the clinical stage. The positive expressions of p53 were related to histological grade. There was a positive relationship between Cox-2 and p53. CONCLUSION: Cyclooxygenase-2 plays an important roles in the process of development, growth and invasion of laryngeal squamous carcinoma; and its inhibitors maybe have effect on the development of laryngeal squamous carcinoma.

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Key concepts: Cyclooxygenase, Immunohistochemistry, Larynx, Pathological, Carcinoma, Laryngeal Neoplasm, Squamous carcinoma, Stage (stratigraphy)