Preventive effect of octreotide combined with sodium hyaluronate on postoperative intraperitoneal adhesions in rabbits

Objective To investigate the preventive effect of octreotide combined with sodium hyaluronate on postoperative abdominal adhesions in rabbits.Methods The established postoperative abdominal adhesion models were divided into 4 groups:(1)without use of octreotide or sodium hyaluronate (model control group); (2)local application of sodium hyaluraronate(HA group) before closure of abdomen; (3)intraperitoneal injection of octreotide (OC group),(4)local application of sodium hyaluronate and peritoneal injection of octreotide 20ug/kg(OC+HA group). relaparotomy was done 14 days later, and the adhesion extent was judged.Results Incidence rates of abdominal adhesion on the day 14 after the operation betweent the 4 groups were not different(P0.05). However,the incidence rates of severe abdominal adhesion were different(P0.05). In OC+HA group was significantly lower than that in the model control group、 octreotide group and HA group (P0.05); and no significant difference between the octreofid group and sodium hyaluronate group (P0.05). Conclusions Combination of octreotide and sodium hyaluronate have the synergetic preventive action on the degree and rate of formation of severe peritoneal adhesions after abdominal operation in rabbits