Catalytic Synthesis of Isopropyl Chloroacetate by Potassium Dodecatungstocobaltate(K_5CoW_(12)O_(40)·3H_2O)

Using potassium dodecatungstocobaltate(K5CoW12O40?3H2O) as catalyst,esterification of chloroacetic acid and isopropyl alcohol was studied.Effect of different factors,such as reaction time,catalyst dosage and ratio of chloroacetic acid to isopropyl alcohol on the yield of isopropyl chloroacetate were carefully analyzed.The experiment results show that the best reaction conditions are as follows: chloroacetic acid is 0.1 mol,ratio of isopropyl alcohol to chloroacetic acid is 1.3,catalyst dosage is 0.5 g,cyclohexane as the deaquation reagent is 10 mL,reaction time is 60 min.Under above conditions,the yield of isopropyl chloroacetate can reach 92.3%.Moreover,the catalyst can be reused for 5 times without obvious loss of activity.