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2009•Progress in Veterinary MedicineRequires access

Mitochondrial Permeability Transition Pore and Its Relationship with Apoptosis

Zhaoxin Tang

Open publisher page 2 citations

Abstract

Mitochondrial permeability transition pore(MPTP),composed of many kinds of protein,is a kind of non-selective and high conductive channel between the inner and out membranes,which also be called megachannel of mitochondria.Many theories support that mitochondrial permeability transition caused by the opening of MPTP is an essential factor resulted in cell death of numerous ways.At present the research on MPTP have a great deal of direction.This article reviewed mainly MPTP structure,MPTP functional mechanism and the relationship with apoptosis.

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What this paper is about

Mitochondrial permeability transition pore(MPTP),composed of many kinds of protein,is a kind of non-selective and high conductive channel between the inner and out membranes,which also be called megachannel of mitochondria.Many theories support that mitochondrial permeability transition caused by the opening of MPTP is an essential factor resulted in cell death of numerous ways.At present the research on MPTP have a great deal of direction.This article reviewed mainly MPTP structure,MPTP functional mechanism and the relationship with apoptosis.

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Available abstract

Mitochondrial permeability transition pore(MPTP),composed of many kinds of protein,is a kind of non-selective and high conductive channel between the inner and out membranes,which also be called megachannel of mitochondria.Many theories support that mitochondrial permeability transition caused by the opening of MPTP is an essential factor resulted in cell death of numerous ways.At present the research on MPTP have a great deal of direction.This article reviewed mainly MPTP structure,MPTP functional mechanism and the relationship with apoptosis.

Key concepts: MPTP, Mitochondrial permeability transition pore, Apoptosis, Mitochondrion, Cell biology, Biophysics, Permeability (electromagnetism), Chemistry

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