Efficacy and safety comparison between olanzapine and haloperidol in the treatment of acute manic episodes

Objective To evaluate the clinical efficacy and safety between olanzapine and haloperidol in the treatment of acute manic episodes. Methods 63 patients with acute mania were divided into an observed group treated with olanzapine and a control group treated with droperidol. The clinical efficacy and adverse reactions in two groups were compared. Results After treatment, 12 h, 72 h, 7 d, 14 d, the PANSS excitement factor score in both two groups patients was decreased, the differences were statistically significant(P0.05). However, it was no significant difference between two groups. All factors of BRMS score for two groups were roughly equal. After 14 d treatment, the efficacy in the patients of observed group and control group was 100% and 96.77% respectively, which was no statistically significant difference between two groups. During treatment, the adverse reactions in observed group were mild, while the adverse reactions in control group almost all belong to the central nervous system TESS factor category. Conclusion The clinical efficacy of olanzapine and haloperidol in treatment of acute manic episodes is very similar, but olanzapine has fewer adverse reactions, and it is worthy of clinical application.