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2003•Medical Journal of West ChinaRequires access

An experimental study of therapeutic effect of Kangxiankeli on dimethyln itrosamine-induced rat liver fibrosis

Xie Chao-liang

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Abstract

Objective To investigate the therapeutic effect of Kangxiankeli(KXKL) on experimental liver fibrosis and to reveal its mechanism. Methods By establishing models of dimethylnitrosamine (DMN)-induced liver fibrosis in rat, we observed the effect of KXKL on content of TNF-α and γ-IFN. Results There was a decline of serum TNF-α and a increase of serum γ-IFN in KXKL group, compared to those of the DMN group (P0.05). Conclusions Our results suggest KXKL has therapeutic effect in DMN-induced rat liver fibrosis ,probably by regulating the cytokine contents of TNF-α and γ-IFN.

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What this paper is about

Objective To investigate the therapeutic effect of Kangxiankeli(KXKL) on experimental liver fibrosis and to reveal its mechanism. Methods By establishing models of dimethylnitrosamine (DMN)-induced liver fibrosis in rat, we observed the effect of KXKL on content of TNF-α and γ-IFN. Results There was a decline of serum TNF-α and a increase of serum γ-IFN in KXKL group, compared to those of the DMN group (P0.05). Conclusions Our results suggest KXKL has therapeutic effect in DMN-induced rat liver fibrosis ,probably by regulating the cytokine contents of TNF-α and γ-IFN.

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Available abstract

Objective To investigate the therapeutic effect of Kangxiankeli(KXKL) on experimental liver fibrosis and to reveal its mechanism. Methods By establishing models of dimethylnitrosamine (DMN)-induced liver fibrosis in rat, we observed the effect of KXKL on content of TNF-α and γ-IFN. Results There was a decline of serum TNF-α and a increase of serum γ-IFN in KXKL group, compared to those of the DMN group (P0.05). Conclusions Our results suggest KXKL has therapeutic effect in DMN-induced rat liver fibrosis ,probably by regulating the cytokine contents of TNF-α and γ-IFN.

Key concepts: Medicine, Liver fibrosis, Therapeutic effect, Fibrosis, Rat model, Cytokine, Tumor necrosis factor alpha, Internal medicine

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