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Meta-analysis on the Relationship between Genetic Polymorphism of Cytochrome P450 2E1 and the Susceptibility to Gastric Cancer in Chinese

Ding Chun-ya

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Abstract

Objective To study the relationship between Cytochrome P450 2E1 genetic polymorphism and susceptibility to gastric cancer in Chinese by means of Meta-analysis. Methods Literature searches in CBMdisc and PubMed were carried out to find relevant papers, and unpublished data were also collected. Odds ratio of CYP2E1 genotype distributions in patients with gastric cancer against healthy control was calculated. The Meta-analysis was applied with RevMan4.2 software for heterogeneity test and pooled OR calculation. Results Of the 6 case-control studies selected for this Meta-analysis, a total of 881 gastric cancer cases and 942 controls were included. The pooled odds ratio of CYP2E1 genotype C1/C1 vs C1/C2+C2/C2 was 1.21(95%CI 0.70-2.12). Conclusion There was not enough evidence currently and further more studies were needed to prove the relationship between CYP2E1 genetic polymorphism and susceptibility to gastric cancer in Chinese residents.

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What this paper is about

Objective To study the relationship between Cytochrome P450 2E1 genetic polymorphism and susceptibility to gastric cancer in Chinese by means of Meta-analysis. Methods Literature searches in CBMdisc and PubMed were carried out to find relevant papers, and unpublished data were also collected. Odds ratio of CYP2E1 genotype distributions in patients with gastric cancer against healthy control was calculated. The Meta-analysis was applied with RevMan4.2 software for heterogeneity test and pooled OR calculation. Results Of the 6 case-control studies selected for this Meta-analysis, a total of 881 gastric cancer cases and 942 controls were included. The pooled odds ratio of CYP2E1 genotype C1/C1 vs C1/C2+C2/C2 was 1.21(95%CI 0.70-2.12). Conclusion There was not enough evidence currently and further more studies were needed to prove the relationship between CYP2E1 genetic polymorphism and susceptibility to gastric cancer in Chinese residents.

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Available abstract

Objective To study the relationship between Cytochrome P450 2E1 genetic polymorphism and susceptibility to gastric cancer in Chinese by means of Meta-analysis. Methods Literature searches in CBMdisc and PubMed were carried out to find relevant papers, and unpublished data were also collected. Odds ratio of CYP2E1 genotype distributions in patients with gastric cancer against healthy control was calculated. The Meta-analysis was applied with RevMan4.2 software for heterogeneity test and pooled OR calculation. Results Of the 6 case-control studies selected for this Meta-analysis, a total of 881 gastric cancer cases and 942 controls were included. The pooled odds ratio of CYP2E1 genotype C1/C1 vs C1/C2+C2/C2 was 1.21(95%CI 0.70-2.12). Conclusion There was not enough evidence currently and further more studies were needed to prove the relationship between CYP2E1 genetic polymorphism and susceptibility to gastric cancer in Chinese residents.

Key concepts: Meta-analysis, CYP2E1, Odds ratio, Genotype, Internal medicine, Medicine, Cancer, Genetic model

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Meta-analysis on the Relationship between Genetic Polymorphism of Cytochrome P450 2E1 and the Susceptibility to Gastric Cancer in Chinese — Research Paper | ScholarLens