Meta-analysis on the Relationship Between Cytochrome P450 2E1 Genetic Polymorphism and Susceptibility to Esophageal Cancer in Chinese

[Objective] To study the relationship between cytochrome P450 2E1 genetic polymorphism and susceptibility to esophageal cancer in Chinese by using Meta-analysis. [Methods] Database CBM and PubMed searches were carried out to collect relevant papers and the literatures were analyzed by Meta-analysis. Odds ratio (OR) of CYP2E1 genotype distributions in cases-control groups was calculated. The Meta-analysis software,RevMan5,was applied for heterogeneity test and pooled OR calculation. [Results] Of the 8 case-control studies selected for the Meta-analysis,totally 879 cases and 1 155 controls were included. The pooled OR of CYP2E1 genotype C1/C1 vs C1/C2+C2/C2 was 2.07 (95% CI = 1.18～3.64). [Conclusion] The relationship between CYP2E1 genetic polymorphism and susceptibility to esophageal cancer in Chinese is significant according to Meta-analysis. CYP2E1 genotype C1/C1 is a risk factor for esophageal cancer.