Effect of Danbaimaimendong Decoction on GAS、PGE_2 of the rats wich chronic atrophic gastritis

Objective: Gastrin(GAS) and prostaglandin E2(PGE2) are influenced by the DanBaimaimendong(DBMMD) decoction on wistar rats suffered from Chronic Atrophic Gastritis(CAG).To study the mechanism of DBMMD in treating CAG.Methods: The Wistar rats had been divided into five groups at random,the normal,the model,the high-dosage,low-dosage of DBMMD and the Vitacoenzyme.The remain groups were made into the model of CAG and administered some medication except the normal group.Then we observed the quantity of GAS and PGE2.Results: The content of GAS and PGE2 in the model group were lower than the normal group,but they were higher in the high-dosage and low-dosage groups than the model.It is notable in high-dosage of DBMMD groups.Conclusion: The GAS and the PGE2 in blood serum of model rats could be heightened obviously by DBMMD.Then hydrochloric acid and Pepsinogen secretions were increased.CAG could be cured through enhancing the recovery of gastric mucosa.