Effects of Resveratrol on Morphology,Anti-oxidation and Immunity Capacity in Erythrocyte of Mice Performing Endurance Exercise

The purpose of this study is to investigate effects of resveratrol on morphology,anti- oxidation and immunity capacity in mice performing endurance exercise.72 Kunming mice were randomly divided into three groups according to weight:group A(Sedentary Control),group B(Endurance exercise)and group C(Resveratrol+Endurance exercise).Administrated of resveratrol with 10 mg/kg/d, the mice of group C were taken incremental load protocol of swimming for six weeks,then had an exhaustive swimming as did the mice of group B.All mice were sacrificed and sampled 24 h later.The following parameters in mice were tested: morphology indexes of erythrocyte,SOD activity and MDA content in erythrocyte,GSH-Px ac- tivity in whole blood and RBC-C_(3b)RR and RBC-ICR.The result shows that the mice perform- ing endurance exercise treated with resveratrol,the deformation ratio of erythrocyte in erythro- cyte significantly decreased,while Hb,HBC and Hct increased compared with endurance mice (P0.05).Resveratrol treatment resulted in significant decrease in MDA content in erythro- cyte of endurance exercise mice(P0.05).However,there were no significant difference in SOD activity in erythrodyte and GSH-Px activity in whole blood between endurance mice and resveratrol+endurance exercise(P0.05),while RBC-C_(3b)RR and RBC-ICR in mice treated with resveratrol increased compared with endurance exercise mice(P0.05).Therefore,it was suggested that reseveratrol had protective effects on erythrocyte in mice performing endur- ance exercise,and enhanced anti-oxidation and immunity capacity of mice performing endurance exercise.