Controlled studies of clinical effectiveness of fluoxetine combined with Olanzapine in depression

Objective: To assess the clinical effectiveness and side effects of fluoxetine combined with olanzapine in depression. Methods: 44 patients with depression (met CCMD-3 diagnostic criteria) were randomly divided into two groups: research group that was given fluoxetine with olanzapine, and controlled group single fluoxetine, dosage of fluoxetine was 20mg/d and olanzapine 2.5mg/d for 6 weeks. Effectiveness and side effects were rated using HAMD and TESS respectively. Results: After 6-week treatment, the excellent rate of the research group was 86.04% and that of the controlled 59.1%, which showed marked difference ( P 0.05),there was significant difference in score-reducing rates of HAMD at the ends of 2nd and 6th weeks between the two groups ( P 0.05 and P 0.01) and no difference of TESS ( P 0.05). Conclusions: The effectiveness of research group is better than that of controlled group in the treatment of depression, and the side effects of the former don't increase.