2013•China Modern DoctorRequires access
Experimental study on the growth inhibition of human glioma U251 cells by lycopene
LI Cheng-lon
Open publisher page 0 citations
Abstract
Objective To discuss the anti-proliferation and inducing apoptosis effects of lycopene on human glioma U251 cells in vitro. Methods The survival rate of U251 cells after 24 h,48 h and 72 h exposure to different concentrations of lycopene were detected by CCK-8;The cell cycle was detected by flow cytometry(FCM). Results Lycopene could inhibit the growth of human glioma U251 cells,and had dose-effect and time-effect relationship(P0.01);FCM testing showed that the cells were mostly blocked in G0/G1 stage;The rate of cell apoptosis induced by lycopene was significantly higher than that in the control group(P0.01),and it was concentration-dependent. Conclusion Lycopene can inhibit the proliferation of U251 cells and induce cells apoptosis.